Transcriptomic analysis of early stages of intestinal regeneration in Holothuria glaberrima.

ABSTRACT: Echinoderms comprise a group of animals with impressive regenerative capabilities. They can replace complex internal organs following injury or autotomy. In holothurians or sea cucumbers, cellular processes of intestinal regeneration have been extensively studied. The molecular machinery behind this faculty, however, remains to be understood. Here we assembled and annotated a de novo transcriptome using RNA-seq data consisting of regenerating and non-regenerating intestinal tissues from the sea cucumber Holothuria glaberrima. Comparisons of differential expression were made using the mesentery as a reference against 24 h and 3 days regenerating intestine, revealing a large number of differentially expressed transcripts. Gene ontology and pathway enrichment analysis showed evidence of incre

SUBMITTER: Quispe-Parra DJ 

PROVIDER: S-EPMC7801731 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature