DNA methylation differences at birth after conception through ART.

ABSTRACT:

Study question

Is there a relation between ART and DNA methylation (DNAm) patterns in cord blood, including any differences between IVF and ICSI?

Summary answer

DNAm at 19 CpGs was associated with conception via ART, with no difference found between IVF and ICSI.

What is known already

Prior studies on either IVF or ICSI show conflicting outcomes, as both widespread effects on DNAm and highly localized associations have been reported. No study on both IVF and ICSI and genome-wide neonatal DNAm has been performed.

Study design, size, duration

This was a cross-sectional study comprising 87 infants conceived with IVF or ICSI and 70 conceived following medically unassisted conception. The requirement for inclusion in the study was an understanding of the Swedish lan

SUBMITTER: Tobi EW 

PROVIDER: S-EPMC7801794 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature