Overexpression of a Long Non-Coding RNA BC037916 is Associated with Pancreatic Tumorigenesis and Poor Prognosis.

ABSTRACT:

Background

Pancreatic cancer is one of the most lethal malignancies. Accumulating evidence supports for the critical contribution of long noncoding RNAs (lncRNAs) to the cancer development and progression. We tried to identify novel lncRNAs involved in the pancreatic carcinogenesis.

Materials and methods

Two independent datasets (Gene Expression Omnibus datasets: GSE16515 and GSE32688) were obtained from the Gene Expression Omnibus (GEO). The level of BC037916 was detected in pancreatic cancer tissues and adjacent no-tumorous tissues (n=86) by qRT-PCR. Effects of BC037916 on proliferation, apoptosis, and invasion of pancreatic cancer cells were examined.

Results

We identified a novel lncRNA BC037916 involved in the pancreatic carcinogenesis by analyzing GEO datasets.

SUBMITTER: Chen G 

PROVIDER: S-EPMC7801918 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature