MicroRNA-320a: an important regulator in the fibrotic process in interstitial lung disease of systemic sclerosis.

ABSTRACT:

Background

Systemic sclerosis (SSc) is an acquired autoimmune disorder characterized by excessive accumulation of collagen and progressive tissue fibrosis. Although interstitial lung disease (ILD) complicates the majority of SSc patients and is the leading cause of death, its pathogenesis remains largely unclear. In the current study, we aimed to evaluate the role of microRNAs in SSc-ILD.

Methods

miRNA expression patterns were assessed by miRNA array and real-time PCR from serum and PBMCs of SSc-ILD patients and healthy controls. Bleomycin-induced SSc-ILD mouse model was used to verify the miRNA expression in the lung tissue. The function of miRNAs in pulmonary fibroblasts was assessed using miRNA inhibitors, and mimics.

Results

miR-320a was significantly downregulate

SUBMITTER: Li Y 

PROVIDER: S-EPMC7802184 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature