Integration of sperm ncRNA-directed DNA methylation and DNA methylation-directed histone retention in epigenetic transgenerational inheritance.

ABSTRACT:

Background

Environmentally induced epigenetic transgenerational inheritance of pathology and phenotypic variation has been demonstrated in all organisms investigated from plants to humans. This non-genetic form of inheritance is mediated through epigenetic alterations in the sperm and/or egg to subsequent generations. Although the combined regulation of differential DNA methylated regions (DMR), non-coding RNA (ncRNA), and differential histone retention (DHR) have been shown to occur, the integration of these different epigenetic processes remains to be elucidated. The current study was designed to examine the integration of the different epigenetic processes.

Results

A rat model of transiently exposed F0 generation gestating females to the agricultural fungicide vinclozolin

SUBMITTER: Beck D 

PROVIDER: S-EPMC7802319 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature