Novel susceptibility loci identified in a genome-wide association study of type 2 diabetes complications in population of Latvia.

ABSTRACT:

Background

Type 2 diabetes complications cause a serious emotional and economical burden to patients and healthcare systems globally. Management of both acute and chronic complications of diabetes, which dramatically impair the quality of patients' life, is still an unsolved issue in diabetes care, suggesting a need for early identification of individuals with high risk for developing diabetes complications.

Methods

We performed a genome-wide association study in 601 type 2 diabetes patients after stratifying them according to the presence or absence of four types of diabetes complications: diabetic neuropathy, diabetic nephropathy, macrovascular complications, and ophthalmic complications.

Results

The analysis revealed ten novel associations showing genome-wide signi

SUBMITTER: Ustinova M 

PROVIDER: S-EPMC7802349 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature