Dataset Information
Novel susceptibility loci identified in a genome-wide association study of type 2 diabetes complications in population of Latvia.
Ontology highlight
ABSTRACT: Background
Type 2 diabetes complications cause a serious emotional and economical burden to patients and healthcare systems globally. Management of both acute and chronic complications of diabetes, which dramatically impair the quality of patients' life, is still an unsolved issue in diabetes care, suggesting a need for early identification of individuals with high risk for developing diabetes complications.Methods
We performed a genome-wide association study in 601 type 2 diabetes patients after stratifying them according to the presence or absence of four types of diabetes complications: diabetic neuropathy, diabetic nephropathy, macrovascular complications, and ophthalmic complications.Results
The analysis revealed ten novel associations showing genome-wide significance, including rs1132787 (GYPA, OR?=?2.71; 95% CI?=?2.02-3.64) and diabetic neuropathy, rs2477088 (PDE4DIP, OR?=?2.50; 95% CI?=?1.87-3.34), rs4852954 (NAT8, OR?=?2.27; 95% CI?=?2.71-3.01), rs6032 (F5, OR?=?2.12; 95% CI?=?1.63-2.77), rs6935464 (RPS6KA2, OR?=?2.25; 95% CI?=?6.69-3.01) and macrovascular complications, rs3095447 (CCDC146, OR?=?2.18; 95% CI?=?1.66-2.87) and ophthalmic complications. By applying the targeted approach of previously reported susceptibility loci we managed to replicate three associations: MAPK14 (rs3761980, rs80028505) and diabetic neuropathy, APOL1 (rs136161) and diabetic nephropathy.Conclusions
Together these results provide further evidence for the implication of genetic factors in the development of type 2 diabetes complications and highlight several potential key loci, able to modify the risk of developing these conditions. Moreover, the candidate variant approach proves a strong and consistent effect for multiple variants across different populations.
SUBMITTER: Ustinova M
PROVIDER: S-EPMC7802349 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Publications
Novel susceptibility loci identified in a genome-wide association study of type 2 diabetes complications in population of Latvia.
BMC medical genomics 20210111 1
<h4>Background</h4>Type 2 diabetes complications cause a serious emotional and economical burden to patients and healthcare systems globally. Management of both acute and chronic complications of diabetes, which dramatically impair the quality of patients' life, is still an unsolved issue in diabetes care, suggesting a need for early identification of individuals with high risk for developing diabetes complications.<h4>Methods</h4>We performed a genome-wide association study in 601 type 2 diabet ...[more]