Association of CETP Gene Variants with Atherogenic Dyslipidemia Among Thai Patients Treated with Statin.

ABSTRACT:

Objective

Patients treated with statins for dyslipidemia may still have a residual risk of atherosclerotic cardiovascular disease (ASCVD). To determine whether genetic variants in the cholesteryl ester transport protein (CETP), rs3764261 (C>A), rs708272 (G>A), and rs12149545 (G>A) affect ASCVD risk, we studied the association of these variants with dyslipidemia in statin-treated patients.

Patients and methods

We included 299 adult Thai patients treated with a statin (95 men and 204 women). Genotyping was performed by conducting a TaqMan real-time polymerase chain reaction-based analysis. We used logistic regression models adjusted for potential confounders of age, body mass index, blood pressure, insulin resistance, and statin dosage to analyze the association between CET

SUBMITTER: Srisawasdi P 

PROVIDER: S-EPMC7802592 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature