Neutrophil-derived granule cargoes: paving the way for tumor growth and progression.

ABSTRACT: Neutrophils are the key cells of our innate immune system mediating host defense via a range of effector functions including phagocytosis, degranulation, and NETosis. For this, they employ an arsenal of anti-microbial cargoes packed in their readily mobilizable granule subsets. Notably, the release of granule content is tightly regulated; however, under certain circumstances, their unregulated release can aggravate tissue damage and could be detrimental to the host. Several constituents of neutrophil granules have also been associated with various inflammatory diseases including cancer. In cancer setting, their excessive release may modulate tissue microenvironment which ultimately leads the way for tumor initiation, growth and metastasis. Neutrophils actively infiltrate within tumor tissu

SUBMITTER: Rawat K 

PROVIDER: S-EPMC7802614 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature