Dissociating the effects of dopamine D2 receptors on effort-based versus value-based decision making using a novel behavioral approach.

ABSTRACT: Cost-benefit decision making is essential for organisms to adapt to their ever-changing environment. Most studies of cost-benefit decision making involve choice conditions in which effort and value are varied simultaneously. This prevents identification of the aspects of cost-benefit decision making that are affected by experimental manipulations. We developed operant assays to isolate the individual impacts of effort and value manipulations on cost-benefit decision making. In the concurrent effort choice (CEC) task, mice choose between exerting two distinct types of effort: the number of responses and the duration of a response, to earn the same reward. By parametrically varying response cost, psychometric functions are obtained that reflect how the two types of effort scale against one a

SUBMITTER: Bailey MR 

PROVIDER: S-EPMC7802819 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature