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Copper-Catalyzed Synthesis of Hindered Ethers from α-Bromo Carbonyl Compounds.

ABSTRACT: A catalytic method for the synthesis of sterically hindered ethers and thioethers from α-bromo carbonyl compounds and the corresponding nucleophiles using an inexpensive Cu(I) catalytic system is reported. This facile transformation takes place at ambient temperature and does not require the exclusion of air or moisture; thus, it is well-suited for the functionalization and derivatization of complex organic molecules.

SUBMITTER: Zhou Z

PROVIDER: S-EPMC7802898 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Copper-Catalyzed Synthesis of Hindered Ethers from α-Bromo Carbonyl Compounds.

Zhou Zhe Z Behnke Nicole Erin NE Kürti László L

Organic letters 20180816 17

A catalytic method for the synthesis of sterically hindered ethers and thioethers from α-bromo carbonyl compounds and the corresponding nucleophiles using an inexpensive Cu(I) catalytic system is reported. This facile transformation takes place at ambient temperature and does not require the exclusion of air or moisture; thus, it is well-suited for the functionalization and derivatization of complex organic molecules. ...[more]

PMID: 30113173

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