Hypoxia-induced mitochondrial abnormalities in cells of the placenta.

ABSTRACT:

Introduction

Impaired utero-placental perfusion is a well-known feature of early preeclampsia and is associated with placental hypoxia and oxidative stress. Although aberrations at the level of the mitochondrion have been implicated in PE pathophysiology, whether or not hypoxia-induced mitochondrial abnormalities contribute to placental oxidative stress is unknown.

Methods

We explored whether abnormalities in mitochondrial metabolism contribute to hypoxia-induced placental oxidative stress by using both healthy term placentae as well as a trophoblast cell line (BeWo cells) exposed to hypoxia. Furthermore, we explored the therapeutic potential of the antioxidants MitoQ and quercetin in preventing hypoxia-induced placental oxidative stress.

Results

Both in placental exp

SUBMITTER: Vangrieken P 

PROVIDER: S-EPMC7802931 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature