Opioid exposure after injury in United States trauma centers: A prospective, multicenter observational study.

ABSTRACT:

Background

Efforts to reduce opioid use in trauma patients are currently hampered by an incomplete understanding of the baseline opioid exposure and variation in United States. The purpose of this project was to obtain a global estimate of opioid exposure following injury and to quantify the variability of opioid exposure between and within United States trauma centers.

Study design

Prospective observational study was performed to calculate opioid exposure by converting all sources of opioids to oral morphine milligram equivalents (MMEs). To estimate variation, an intraclass correlation was calculated from a multilevel generalized linear model adjusting for the a priori selected variables Injury Severity Score and prior opioid use.

Results

The centers enrolled 1,731 p

SUBMITTER: Harvin JA 

PROVIDER: S-EPMC7802946 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature