Efficient gene expression signature for a breast cancer immuno-subtype.

ABSTRACT:

Motivation and background

The patient's immune system plays an important role in cancer pathogenesis, prognosis and susceptibility to treatment. Recent work introduced an immune related breast cancer. This subtyping is based on the expression profiles of the tumor samples. Specifically, one study showed that analyzing 658 genes can lead to a signature for subtyping tumors. Furthermore, this classification is independent of other known molecular and clinical breast cancer subtyping. Finally, that study shows that the suggested subtyping has significant prognostic implications.

Results

In this work we develop an efficient signature associated with survival in breast cancer. We begin by developing a more efficient signature for the above-mentioned breast cancer immune-based sub

SUBMITTER: Galili B 

PROVIDER: S-EPMC7802952 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature