The SUMOylation pathway suppresses arbovirus replication in Aedes aegypti cells.

ABSTRACT: Mosquitoes are responsible for the transmission of many clinically important arboviruses that cause significant levels of annual mortality and socioeconomic health burden worldwide. Deciphering the mechanisms by which mosquitoes modulate arbovirus infection is crucial to understand how viral-host interactions promote vector transmission and human disease. SUMOylation is a post-translational modification that leads to the covalent attachment of the Small Ubiquitin-like MOdifier (SUMO) protein to host factors, which in turn can modulate their stability, interaction networks, sub-cellular localisation, and biochemical function. While the SUMOylation pathway is known to play a key role in the regulation of host immune defences to virus infection in humans, the importance of this pathway during

SUBMITTER: Stokes S 

PROVIDER: S-EPMC7802965 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature