Cardiovascular medications and regulation of COVID-19 receptors expression.

ABSTRACT:

Introduction

Emerging epidemiological studies suggested that Renin-Angiotensin-Aldosterone system (RAAS) inhibitors may increase infectivity and severity of COVID-19 by modulating the expression of ACE2.

Methods

In silico analysis was conducted to compare the blood expression levels of SARS-CoV-2 entry genes between age and gender matched cohort of hypertensive patients versus control, and to determine the effect of common cardiovascular medications on the expression of COVID-19 receptors in vitro using primary human hepatocytes.

Results

The transcriptomic analysis revealed a significant increase of ACE2 and TMPRSS2 in the blood of patients with hypertension. Treatment of primary human hepatocytes with captopril, but not enalapril, significantly increased ACE2 express

SUBMITTER: Saheb Sharif-Askari N 

PROVIDER: S-EPMC7803030 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature