Urate, Blood Pressure, and Cardiovascular Disease: Evidence From Mendelian Randomization and Meta-Analysis of Clinical Trials.

ABSTRACT: Serum urate has been implicated in hypertension and cardiovascular disease, but it is not known whether it is exerting a causal effect. To investigate this, we performed Mendelian randomization analysis using data from UK Biobank, Million Veterans Program and genome-wide association study consortia, and meta-analysis of randomized controlled trials. The main Mendelian randomization analyses showed that every 1-SD increase in genetically predicted serum urate was associated with an increased risk of coronary heart disease (odds ratio, 1.19 [95% CI, 1.10-1.30]; P=4×10^-5), peripheral artery disease (1.12 [95% CI, 1.03-1.21]; P=9×10^-3), and stroke (1.11 [95% CI, 1.05-1.18]; P=2×10^-4). In Mendelian randomization mediation analyses, elevated

SUBMITTER: Gill D 

PROVIDER: S-EPMC7803439 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature