Direct Actions of AT₁ (Type 1 Angiotensin) Receptors in Cardiomyocytes Do Not Contribute to Cardiac Hypertrophy.

ABSTRACT: Activation of AT₁ (type 1 Ang) receptors stimulates cardiomyocyte hypertrophy in vitro. Accordingly, it has been suggested that regression of cardiac hypertrophy associated with renin-Ang system blockade is due to inhibition of cellular actions of Ang II in the heart, above and beyond their effects to reduce pressure overload. We generated 2 distinct mouse lines with cell-specific deletion of AT_1A receptors, from cardiomyocytes. In the first line (C-SMKO), elimination of AT_1A receptors was achieved using a heterologous Cre recombinase transgene under control of the Sm22 promoter, which expresses in cells of smooth muscle lineage including cardiomyocytes and vascular smooth muscle cells of conduit but not resistance vessels. The second line (R-

SUBMITTER: Sparks MA 

PROVIDER: S-EPMC7803456 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature