Association and functional study between ADIPOQ and metabolic syndrome in elderly Chinese Han population.

ABSTRACT:

Objective

Metabolic syndrome (MetS) is a cluster of health problems that places individuals at higher risk of developing cardiovascular disease, diabetes and stroke. The prevalence of MetS is increasing worldwide. It is also well accepted that genetic and environmental factors play significant roles in the occurrence/development of MetS, but studies exploring genetic factors are still lacking. Here, we aimed to investigate the association of ADIPOQ gene variants with MetS in an elderly Chinese Han population.

Results

We found that the allelic frequencies of rs6773957 and rs3774261 were significantly different between MetS and the control (p = 0.031; p = 0.049). Furthermore, a reduction in luciferase activity was observed when HEK293T cells were transfect

SUBMITTER: Wang Q 

PROVIDER: S-EPMC7803488 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature