The impact of physical frailty on the response to inactivated influenza vaccine in older adults.

ABSTRACT: Physical frailty's impact on hemagglutination inhibition antibody titers (HAI) and peripheral blood mononuclear cell (PBMC) transcriptional responses after influenza vaccination is unclear. Physical frailty was assessed using the 5-item Fried frailty phenotype in 168 community- and assisted-living adults ≥55 years of age during an observational study. Blood was drawn before, 3, 7, and 28 days post-vaccination with the 2017-2018 inactivated influenza vaccine. HAI response to the A/H1N1 strain was measured at Days 0 and 28 using seropositivity, seroconversion, log₂ HAI titers, and fold-rise in log₂ HAI titers. RNA sequencing of PBMCs from Days 0, 3 and 7 was measured in 28 participants and compared using pathway analyses. Frailty was not significantly associated with an

SUBMITTER: Moehling KK 

PROVIDER: S-EPMC7803506 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature