Effect of paternal age on offspring birth defects: a systematic review and meta-analysis.

ABSTRACT:

Objective

This systematic review and meta-analysis was aimed at determining whether paternal age is a risk factor for offspring birth defects.

Results

A total of 38 and 11 studies were included in the systematic review and meta-analysis, respectively. Compared with reference, fathers aged 25 to 29, young fathers (< 20 years) could increase the risk of urogenital abnormalities (OR: 1.50, 95 % CI: 1.03-2.19) and chromosome disorders (OR: 1.38, 95 % CI: 1.12-1.52) in their offsprings; old fathers (≥ 40 years) could increase the risk of cardiovascular abnormalities (OR: 1.10, 95 % CI: 1.01-1.20), facial deformities (OR: 1.08, 95 % CI: 1.00-1.17), urogenital abnormalities (OR: 1.28, 95 % CI: 1.07-1.52), and chromosome disorders (OR: 1.30, 95 % CI: 1.12-1.52).

Conclusions

O

SUBMITTER: Fang Y 

PROVIDER: S-EPMC7803514 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature