Identification of novel prognostic biomarkers in renal cell carcinoma.

ABSTRACT:

Objective

To identify novel prognostic biomarkers in renal cell carcinoma (RCC).

Results

12 coding genes and one miRNA were finally identified as prognostic biomarkers. All of them were related to a poor prognosis. Lower expression levels of the coding genes were observed in higher clinical stages. Prognostic signatures including 7 biomarkers were identified. Patients in the high-risk group had worse survival than those in the low-risk group. The areas under the curves in different years indicated that it was a valuable signature in prognosis. It was found that elevated WDR72 inhibited the survival and invasion of 786-O and 769P cells in vitro.

Conclusions

Thirteen prognostic biomarkers of RCC were identified. Among them, 7 biomarkers comprised a signature to e

SUBMITTER: Zou Y 

PROVIDER: S-EPMC7803519 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature