Time gap between the onset and diagnosis in Werner syndrome: a nationwide survey and the 2020 registry in Japan.

ABSTRACT: Patients with Werner syndrome present with diverse signs of aging that begin in adolescence. A Japanese nationwide survey was conducted to establish a registry that could clarify the disease profile of patients with Werner syndrome. The questionnaires were sent to 7888 doctors. The survey identified 116 patients diagnosed with Werner syndrome based on the diagnosis criteria. Forty patients were enrolled in the registry. Data on clinical symptoms, treatment information, and laboratory examination from patients who provided informed consent were collected. The data at enrollment were analyzed. The patients' average age at enrollment was 50.1±7.5 years. The mean onset age was 26.1±9.5 years, but the mean age at diagnosis was 42.5±8.6 years. Average height and weight of the study patients were

SUBMITTER: Koshizaka M 

PROVIDER: S-EPMC7803551 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature