A glycolysis-related gene signature predicts prognosis of patients with esophageal adenocarcinoma.

ABSTRACT:

Background

Esophageal adenocarcinoma (EAC) is a growing problem with a rapidly rising incidence and carries a poor prognosis. We aimed to develop a glycolysis-related gene signature to predict the prognostic outcome of patients with EAC.

Results

Five genes (CLDN9, GFPT1, HMMR, RARS and STMN1) were correlated with prognosis of EAC patients. Patients were classified into high-risk and low-risk groups calculated by Cox regression analysis, based on the five gene signature risk score. The five-gene signature was an independent biomarker for prognosis and patients with low risk scores showed better prognosis. Nomogram incorporating the gene signature and clinical prognostic factors was effective in predicting the overall survival.

Conclusion

An innovative identified glycol

SUBMITTER: Kang H 

PROVIDER: S-EPMC7803571 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature