Identification of Novel Genetic Variants Related to Trabecular Bone Score in Community-Dwelling Older Adults.

ABSTRACT:

Background

As the genetic variants of trabecular bone microarchitecture are not well-understood, we performed a genome-wide association study to identify genetic determinants of bone microarchitecture analyzed by trabecular bone score (TBS).

Methods

TBS-associated genes were discovered in the Ansung cohort (discovery cohort), a community-based rural cohort in Korea, and then validated in the Gene-Environment Interaction and Phenotype (GENIE) cohort (validation cohort), consisting of subjects who underwent health check-up programs. In the discovery cohort, 2,451 participants were investigated for 1.42 million genotyped and imputed markers.

Results

In the validation cohort, identified as significant variants were evaluated in 2,733 participants. An intronic variant in i

SUBMITTER: Kong SH 

PROVIDER: S-EPMC7803610 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature