Determinants of Bacille Calmette-Guerin scarification in Danish children.

ABSTRACT:

Background

Studies in low-income countries have shown that among Bacille Calmette-Guérin (BCG) vaccinated children, those who develop a BCG-scar have significantly better survival than those who do not develop a scar. In a Danish multicenter randomized clinical trial we assessed determinants for developing a BCG-scar and for BCG scar size following neonatal BCG vaccination.

Methods

At three Danish hospitals, newborns were randomized 1:1 to BCG vaccination or no BCG vaccination. The infants were invited for a clinical examination at the ages of 3 and 13 months. At 13 months, the scar site was inspected and scar size measured. We investigated three groups of determinants; external, parental, and individual-level determinants on relative scar prevalence and differences in media

SUBMITTER: Jensen TM 

PROVIDER: S-EPMC7803645 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature