Ontology highlight
ABSTRACT:
SUBMITTER: Collins B
PROVIDER: S-EPMC7803671 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Neuron 20200910 3
Although the mammalian rest-activity cycle is controlled by a "master clock" in the suprachiasmatic nucleus (SCN) of the hypothalamus, it is unclear how firing of individual SCN neurons gates individual features of daily activity. Here, we demonstrate that a specific transcriptomically identified population of mouse VIP+ SCN neurons is active at the "wrong" time of day-nighttime-when most SCN neurons are silent. Using chemogenetic and optogenetic strategies, we show that these neurons and their ...[more]