Perlecan Domain-V Enhances Neurogenic Brain Repair After Stroke in Mice.

ABSTRACT: The extracellular matrix fragment perlecan domain V is neuroprotective and functionally restorative following experimental stroke. As neurogenesis is an important component of chronic post-stroke repair, and previous studies have implicated perlecan in developmental neurogenesis, we hypothesized that domain V could have a broad therapeutic window by enhancing neurogenesis after stroke. We demonstrated that domain V is chronically increased in the brains of human stroke patients, suggesting that it is present during post-stroke neurogenic periods. Furthermore, perlecan deficient mice had significantly less neuroblast precursor cells after experimental stroke. Seven-day delayed domain V administration enhanced neurogenesis and restored peri-infarct excitatory synaptic drive to neocortical la

SUBMITTER: Trout AL 

PROVIDER: S-EPMC7803718 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature