The impact of moderate and severe asthma exacerbations on quality of life: a post hoc analysis of randomised controlled trial data.

ABSTRACT:

Background

This paper reports the duration of moderate and severe exacerbations in patients with house dust mite induced allergic asthma and the impact on patients' quality of life.

Methods

Post-hoc analyses were conducted using data collected during a phase III multi-national trial (MT-04) that investigated time to moderate or severe asthma exacerbation among 485 patients during withdrawal from inhaled corticosteroids. Patient diaries were analysed to ascertain duration of exacerbations. The impact on patients' quality of life was measured by calculating utilities for five health states using the EuroQol-5 Dimension (EQ-5D-3L) and Asthma Quality of Life Questionnaire (AQL-5D). A regression analysis predicted the disutility of moving from 'well controlled asthma' to the othe

SUBMITTER: Briggs A 

PROVIDER: S-EPMC7803866 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature