Preliminary evidence for conserved transcriptional response to adversity in adults with temporomandibular disorder.

ABSTRACT: Temporomandibular disorder (TMD) is one of the most common orofacial pain conditions. Alteration in immune functioning is one promising biological mechanism underlying pain in TMD. However, there is a gap in the understanding of molecular bases contributing to altered immune functioning in these patients.

Objectives

In the current study, we investigated whether individuals with TMD would exhibit differential activity of 3 specific transcription factors involved in inflammatory (nuclear factor-kappa B, NF-kB), antiviral (interferon-regulatory factors, IRF), and sympathetic (cAMP response element-binding protein, CREB) processes using a promoter-based bioinformatics analysis, which is characterized as the "Conserved Transcriptional Response to Adversity."

Methods

Adults with TM

SUBMITTER: King CD 

PROVIDER: S-EPMC7803915 | biostudies-literature | 2021 Jan-Feb

REPOSITORIES: biostudies-literature