High-salt intake affects retinal vascular tortuosity in healthy males: an exploratory randomized cross-over trial.

ABSTRACT: The retinal microcirculation is increasingly receiving credit as a relatively easily accessible microcirculatory bed that correlates closely with clinical cardiovascular outcomes. The effect of high salt (NaCl) intake on the retinal microcirculation is currently unknown. Therefore, we performed an exploratory randomized cross-over dietary intervention study in 18 healthy males. All subjects adhered to a two-week high-salt diet and low-salt diet, in randomized order, after which fundus photographs were taken and assessed using a semi-automated computer-assisted program (SIVA, version 4.0). Outcome parameters involved retinal venular and arteriolar tortuosity, vessel diameter, branching angle and fractal dimension. At baseline, participants had a mean (SD) age of 29.8 (4.4) years and blood p

SUBMITTER: Wenstedt EFE 

PROVIDER: S-EPMC7803999 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature