Period1 mediates rhythmic metabolism of toxins by interacting with CYP2E1.

ABSTRACT: The biological clock is an endogenous biological timing system, which controls metabolic functions in almost all organs. Nutrient metabolism, substrate processing, and detoxification are circadian controlled in livers. However, how the clock genes respond to toxins and influence toxicity keeps unclear. We identified the clock gene Per1 was specifically elevated in mice exposed to toxins such as carbon tetrachloride (CCl₄). Mice lacking Per1 slowed down the metabolic rate of toxins including CCl₄, capsaicin, and acetaminophen, exhibiting relatively more residues in the plasma. Liver injury and fibrosis induced by acute and chronic CCl₄ exposure were markedly alleviated in Per1-deficient mice. These processes involved the binding of PER1 protein and hepatocyt

SUBMITTER: Ge W 

PROVIDER: S-EPMC7804260 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature