BMP signaling suppresses Gemc1 expression and ependymal differentiation of mouse telencephalic progenitors.

ABSTRACT: The lateral ventricles of the adult mammalian brain are lined by a single layer of multiciliated ependymal cells, which generate a flow of cerebrospinal fluid through directional beating of their cilia as well as regulate neurogenesis through interaction with adult neural stem cells. Ependymal cells are derived from a subset of embryonic neural stem-progenitor cells (NPCs, also known as radial glial cells) that becomes postmitotic during the late embryonic stage of development. Members of the Geminin family of transcriptional regulators including GemC1 and Mcidas play key roles in the differentiation of ependymal cells, but it remains largely unclear what extracellular signals regulate these factors and ependymal differentiation during embryonic and early-postnatal development. We now show

SUBMITTER: Omiya H 

PROVIDER: S-EPMC7804439 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature