An in vivo model allowing continuous observation of human vascular formation in the same animal over time.

ABSTRACT: Angiogenesis contributes to numerous pathological conditions. Understanding the molecular mechanisms of angiogenesis will offer new therapeutic opportunities. Several experimental in vivo models that better represent the pathological conditions have been generated for this purpose in mice, but it is difficult to translate results from mouse to human blood vessels. To understand human vascular biology and translate findings into human research, we need human blood vessel models to replicate human vascular physiology. Here, we show that human tumor tissue transplantation into a cranial window enables engraftment of human blood vessels in mice. An in vivo imaging technique using two-photon microscopy allows continuous observation of human blood vessels until at least 49 days after tumor trans

SUBMITTER: Tsukada Y 

PROVIDER: S-EPMC7804448 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature