DNAJB4 identified as a potential breast cancer marker: evidence from bioinformatics analysis and basic experiments.

ABSTRACT:

Background

Breast cancer (BC) is the leading cause of tumor-related death in women worldwide, but its pathogenesis is not clear. The efficient screening of new therapeutic targets for BC through bioinformatics and biological experimental techniques has become a hot topic in BC research.

Methods

The bioinformatics method was used to analyze the gene chips and obtain the hub genes, playing an important role in the development of BC. The biological processes (BP) involved in the hub genes were analyzed by Bingo, and the impact of each hub gene on disease-free survival (DFS) and overall survival (OS) in BC patients was evaluated in the Kaplan-Meier Plotter database. The expression of DNAJB4, the hub gene with the greatest degree and having an effect on the prognosis of BC

SUBMITTER: Mo L 

PROVIDER: S-EPMC7804547 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature