CT quantification of the heterogeneity of fibrosis boundaries in idiopathic pulmonary fibrosis.

ABSTRACT:

Objectives

To quantify the heterogeneity of fibrosis boundaries in idiopathic pulmonary fibrosis (IPF) using the Gaussian curvature analysis for evaluating disease severity and predicting survival.

Methods

We retrospectively included 104 IPF patients and 52 controls who underwent baseline chest CT scans. Normal lungs below - 500 HU were segmented, and the boundary was three-dimensionally reconstructed using in-house software. Gaussian curvature analysis provided histogram features on the heterogeneity of the fibrosis boundary. We analyzed the correlations between histogram features and the gender-age-physiology (GAP) and CT fibrosis scores. We built a regression model to predict diffusing capacity of carbon monoxide (DLCO) using the histogram features and calculated the modi

SUBMITTER: Park J 

PROVIDER: S-EPMC7804589 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature