Severe injury-induced osteoporosis and skeletal muscle mineralization: Are these related complications?

ABSTRACT: Severely injured patients are beleaguered by complications during convalescence, such as dysregulated biomineralization. Paradoxically, severely injured patients experience the loss of bone (osteoporosis), resulting in diminished skeletal integrity and increased risk of fragility fractures; yet they also accrue mineralization in soft tissues, resulting in complications such as heterotopic ossification (HO). The pathophysiology leading to dysregulated biomineralization in severely injured patients is not well defined. It has been postulated that these pathologies are linked, such that mineralization is "transferred" from the bone to soft tissue compartments. The goal of this study was to determine if severe injury-induced osteoporosis and soft tissue calcification are temporally coincident

SUBMITTER: Moore-Lotridge SN 

PROVIDER: S-EPMC7804603 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature