Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19.

ABSTRACT:

Objective

Although COVID-19 is primarily a respiratory illness, there is mounting evidence suggesting that the GI tract is involved in this disease. We investigated whether the gut microbiome is linked to disease severity in patients with COVID-19, and whether perturbations in microbiome composition, if any, resolve with clearance of the SARS-CoV-2 virus.

Methods

In this two-hospital cohort study, we obtained blood, stool and patient records from 100 patients with laboratory-confirmed SARS-CoV-2 infection. Serial stool samples were collected from 27 of the 100 patients up to 30 days after clearance of SARS-CoV-2. Gut microbiome compositions were characterised by shotgun sequencing total DNA extracted from stools. Concentrations of inflammatory cytokines and blood markers wer

SUBMITTER: Yeoh YK 

PROVIDER: S-EPMC7804842 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature