Effect of Exposure to e-Cigarettes With Salt vs Free-Base Nicotine on the Appeal and Sensory Experience of Vaping: A Randomized Clinical Trial.

ABSTRACT:

Importance

Alkaline free-base nicotine is bitter and a respiratory irritant. High-nicotine electronic cigarette (e-cigarette) products contain acid additives that change nicotine from a free-base to a protonated salt chemical form, which could improve the sensory experience of vaping, particularly among never smokers unaccustomed to inhaling free-base nicotine.

Objective

To determine whether exposure to e-cigarettes with salt vs free-base nicotine formulations improves the appeal and sensory experience of vaping e-cigarettes and whether nicotine formulation effects differ by e-cigarette flavor and ever combustible cigarette smoking status.

Design, setting, and participants

Single-visit double-blind within-participant randomized clinical trial was conducted in an acade

SUBMITTER: Leventhal AM 

PROVIDER: S-EPMC7804919 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature