The AMPAR antagonist perampanel protects the neurovascular unit against traumatic injury via regulating Sirt3.

ABSTRACT:

Introduction

Perampanel is a highly selective and noncompetitive α-amino-3 -hydroxy-5-methyl-4-isoxazole propionate receptor (AMPAR) antagonist, which has been used as an orally administered antiepileptic drug in more than 55 countries. Recently, perampanel was shown to exert neuroprotective effects in hemorrhagic and ischemic stroke models via regulating blood-brain barrier (BBB) function.

Aim

Here, the protective effects of perampanel were investigated in an in vitro neurovascular unit (NVU) system established using a triple cell co-culture model (neurons, astrocytes, and brain microvascular endothelial cells) and in an in vivo traumatic brain injury (TBI) model.

Results

Neurons in the NVU system exhibit a more mature morphological phenotype compared with neurons cu

SUBMITTER: Chen T 

PROVIDER: S-EPMC7804923 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature