Ontology highlight
ABSTRACT:
SUBMITTER: Li B
PROVIDER: S-EPMC7804955 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Li Botai B Zhu Lili L Lu Chunlai C Wang Cun C Wang Hui H Jin Haojie H Ma Xuhui X Cheng Zhuoan Z Yu Chengtao C Wang Siying S Zuo Qiaozhu Q Zhou Yangyang Y Wang Jun J Yang Chen C Lv Yuanyuan Y Jiang Liyan L Qin Wenxin W
Nature communications 20210112 1
Circular RNAs (circRNA) are a class of covalently closed single-stranded RNAs that have been implicated in cancer progression. Here we identify circNDUFB2 to be downregulated in non-small cell lung cancer (NSCLC) tissues, and to negatively correlate with NSCLC malignant features. Elevated circNDUFB2 inhibits growth and metastasis of NSCLC cells. Mechanistically, circNDUFB2 functions as a scaffold to enhance the interaction between TRIM25 and IGF2BPs, a positive regulator of tumor progression and ...[more]