Association between antinuclear antibody seropositivity and telomere length: a nationwide population-based study.

ABSTRACT:

Objectives

Telomere shortening is a well-established marker of biological aging. Whether telomere erosion coincides with age-related increases in antinuclear antibody (ANA) seropositivity remains unknown. Our study aimed to determine the association between ANA seropositivity and shortened telomeres among 1999-2002 National Health and Nutrition Examination Survey (NHANES) subjects.

Methods

We performed a cross-sectional analysis of 2,188 NHANES study participants with available ANA and telomere length data. ANA testing was performed using indirect immunofluorescence. Telomere lengths were measured via quantitative polymerase chain reaction methods. Applying appropriate sample weighting techniques, we used univariate and multivariate logistic regression methods to assess the

SUBMITTER: Natalini JG 

PROVIDER: S-EPMC7805007 | biostudies-literature | 2020 Sep-Oct

REPOSITORIES: biostudies-literature