Environment Controls Biomolecule Release from Dynamic Covalent Hydrogels.

ABSTRACT: Moldable hydrogels composed of dynamic covalent bonds are attractive biomaterials for controlled release, as the dynamic exchange of bonds in these networks enables minimally invasive application via injection. Despite the growing interest in the biomedical application of dynamic covalent hydrogels, there is a lack of fundamental understanding as to how the network design and local environment control the release of biomolecules from these materials. In this work, we fabricated boronic-ester-based dynamic covalent hydrogels for the encapsulation and in vitro release of a model biologic (β-galactosidase). We systematically investigated the role of network properties and of the external environment (temperature and presence of competitive binders) on release from these dynamic covalent hydro

SUBMITTER: Marco-Dufort B 

PROVIDER: S-EPMC7805009 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature