Protective effect of 6-paradol in acetic acid-induced ulcerative colitis in rats.

ABSTRACT:

Background

Ulcerative colitis is a gut inflammatory disorder due to altered immune response to gut microbiome, with interplay of environmental and genetic factors. TNF-α activates inflammatory response through a cascade of immune responses, augmenting pro-inflammatory mediators and proteases, activating chemotaxis, and infiltration of inflammatory cells, leading to ulceration and haemorrhage through cytotoxic reactive oxygen species. 6-Paradol, a dietary component in several plants belonging to the Zingiberaceae family, has shown anti-inflammatory and antioxidant activities. Current study evaluates the effect of 6-paradol in amelioration of ulcerative colitis in rats for the first time.

Methods

6-Paradol (95% purity) was obtained from seeds of Aframomum melegueta. Rats were

SUBMITTER: Rafeeq M 

PROVIDER: S-EPMC7805070 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature