Targetable alterations in invasive pleomorphic lobular carcinoma of the breast.

ABSTRACT:

Background

Invasive pleomorphic lobular carcinoma (PLC) of the breast is a subtype of invasive lobular cancer which compromises approximately 1% of all epithelial breast malignancies and is characterized by higher nuclear pleomorphism and poorer prognosis than classic invasive lobular cancer (ILC). Since PLC is more aggressive than classical ILC, we examined the underlying molecular alterations in this subtype of breast cancer to understand the possible benefit from targeted therapies.

Methods

In this study, we investigate the clinical characteristics and molecular alterations in 16 PLC from our institution. Additionally, we examined the clinical and genomic features in 31 PLC from the Cancer Genome Atlas (TCGA).

Results

Overall, our analysis of PLC found that 28% had

SUBMITTER: Riedlinger GM 

PROVIDER: S-EPMC7805167 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature