Pattern of cortical thinning in logopenic progressive aphasia patients in Thailand.

ABSTRACT:

Background

Logopenic progressive aphasia (LPA) is an uncommon neurodegenerative disorder primarily characterized by word-finding difficulties and sentence repetition impairment. Prominent cortical atrophy around left temporo-parietal junction (TPJ) is a classical imaging feature of LPA. This study investigated cortical thinning pattern in clinically diagnosed LPA patients using non-demented subjects as a control group. We also aimed to explore whether there was prominent thinning of other cortical area additional to the well-recognized left TPJ.

Methods

Thicknesses of all cortical regions were measured from brain magnetic resonance images using an automated command on Freesurfer software. Cortical thickness of the LPA and control groups were compared by two methods: 1) using

SUBMITTER: Thanprasertsuk S 

PROVIDER: S-EPMC7805202 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature