Prevalence and Outcomes of Concomitant Aortic Stenosis and Cardiac Amyloidosis.

ABSTRACT:

Background

Older patients with severe aortic stenosis (AS) are increasingly identified as having cardiac amyloidosis (CA). It is unknown whether concomitant AS-CA has worse outcomes or results in futility of transcatheter aortic valve replacement (TAVR).

Objectives

This study identified clinical characteristics and outcomes of AS-CA compared with lone AS.

Methods

Patients who were referred for TAVR at 3 international sites underwent blinded research core laboratory ^99mtechnetium-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) bone scintigraphy (Perugini grade 0: negative; grades 1 to 3: increasingly positive) before intervention. Transthyretin-CA (ATTR) was diagnosed by DPD and absence of a clonal immunoglobulin, and light-chain CA (AL) was diagnosed via

SUBMITTER: Nitsche C 

PROVIDER: S-EPMC7805267 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature