Cardiovascular risk factor mediation of the effects of education and Genetic Risk Score on cardiovascular disease: a prospective observational cohort study of the Framingham Heart Study.

ABSTRACT:

Objectives

Level of education and genetic risk are key predictors of cardiovascular disease (CVD). While several studies have explored the causal mechanisms of education effects, it remains uncertain to what extent genetic risk is mediated by established CVD risk factors. This study sought to investigate this and explored the mediation of education and genetic effects on CVD by established cardiovascular risk factors in the Framingham Heart Study (FHS).

Design

Prospective observational cohort study.

Participants

7017 participants from the FHS.

Setting

Community-based cohort of adults in Framingham, Massachusetts, USA.

Primary outcome measure

Incident CVD. The total effects of education and genetic predisposition using a 63-variant genetic risk score (GRS

SUBMITTER: Powell KL 

PROVIDER: S-EPMC7805364 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature