Iron deficiency promotes aortic medial degeneration via destructing cytoskeleton of vascular smooth muscle cells.

ABSTRACT:

Background

Aortic dissection (AD) and aortic aneurysm (AA) are critical illnesses with an unclear pathogenetic mechanism that seriously threaten human life. Aortic medial degeneration (AMD) is the main pathological feature of AD and AA. Diseases of iron metabolism can cause a variety of physiological dysfunctions. In this study, we aimed to clarify the state of iron metabolism in patients with AD and AA, and to explore the effect of iron metabolism on AMD.

Methods

A total of 200 patients with AD or AA, and 60 patients with hypertension were included in the study. Blood samples were drawn immediately when patients were admitted to the hospital. Aortic specimens from patients with Stanford type A AD were obtained at the time of surgery. The status of iron metabolism in the cir

SUBMITTER: Li B 

PROVIDER: S-EPMC7805404 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature