Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients.

ABSTRACT:

Background

The SARS-CoV-2 pandemic is currently leading to increasing numbers of COVID-19 patients all over the world. Clinical presentations range from asymptomatic, mild respiratory tract infection, to severe cases with acute respiratory distress syndrome, respiratory failure, and death. Reports on a dysregulated immune system in the severe cases call for a better characterization and understanding of the changes in the immune system.

Methods

In order to dissect COVID-19-driven immune host responses, we performed RNA-seq of whole blood cell transcriptomes and granulocyte preparations from mild and severe COVID-19 patients and analyzed the data using a combination of conventional and data-driven co-expression analysis. Additionally, publicly available data was used to show

SUBMITTER: Aschenbrenner AC 

PROVIDER: S-EPMC7805430 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature