Role of spatial patterning of N-protein interactions in SARS-CoV-2 genome packaging.

ABSTRACT: Viruses must efficiently and specifically package their genomes while excluding cellular nucleic acids and viral sub-genomic fragments. Some viruses use specific packaging signals, which are conserved sequence/structure motifs present only in the full-length genome. Recent work has shown that viral proteins important for packaging can undergo liquid-liquid phase separation (LLPS), where one or two viral nucleic acid binding proteins condense with the genome. The compositional simplicity of viral components lends itself well to theoretical modeling compared to more complex cellular organelles. Viral LLPS can be limited to one or two viral proteins and a single genome that is enriched in LLPS-promoting features. In our previous study, we observed that LLPS-promoting sequences of SARS-CoV-2 a

SUBMITTER: Seim I 

PROVIDER: S-EPMC7805453 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature